The current results may contribute to differences in adolescent cognitive regulation of emotion. This was dictated by both weak recruitment of inhibition in LAT and weak excitatory effects of PFC in BA. In addition, stimulation of either prelimbic or infralimbic PFC evokes weaker inhibition over basal (BA) and lateral (LAT) nuclei of the BLA in adolescents. Using in vivo extracellular electrophysiological recordings from anesthetized male rats we found that in vivo summation of PFC inputs to the BLA was less regulated by GABAergic inhibition in adolescents (postnatal day 39) than adults (postnatal day 72–75). The purpose of this study was to determine whether PFC regulation over basolateral amygdala area (BLA) in vivo is immature in adolescence, and if this is due to immaturity of GABAergic elements or PFC excitatory inputs. The cellular substrates for this regulation may include PFC activation of inhibitory GABAergic elements in the amygdala. This occurs in parallel with maturation of prefrontal cortical (PFC) regulation over the amygdala. Cognitive regulation of emotion develops from childhood into adulthood.
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